Pluronic F-127: Description and Application

Pluronic F-127 is a nonionic surfactant commonly used to improve the solubilization of hydrophobic compounds, including cell-permeable AM esters such as Fluo-4 and Fluo-8 calcium indicators, as well as Di-4-ANEPS and Di-8-ANEPS potentiometric probes. It also helps facilitate the efficient uptake of these compounds into cells.

We offer Pluronic F-127 in a ready-to-use 10% aqueous solution, making it convenient for laboratory use and reducing the time required for preparation.

A common application of the 10% Pluronic F-127 aqueous solution is to support the cellular loading of AM ester ion indicators and other fluorescent dyes. The specific loading conditions may differ depending on the cell type and the compounds being used.

Polyethylene-polypropylene glycol Chemical Properties

Safety Information

Product Application of Polyethylene-Polypropylene Glycol CAS#9003-11-6

Polyethylene-polypropylene glycol is a nonionic polyoxyethylene–polyoxypropylene copolymer commonly used in pharmaceutical formulations as an emulsifier and solubilizing agent. Its hydrophilic polyoxyethylene segments and hydrophobic polyoxypropylene segments work together to provide effective surface-active properties.

Although different grades of polyethylene-polypropylene glycol have a similar chemical composition, they mainly differ in the proportions of ethylene oxide and propylene oxide incorporated during production. These variations result in a broad range of physical and surfactant properties, allowing the material to be supplied in multiple commercial grades.

In pharmaceutical formulations, polyethylene-polypropylene glycol is widely used as an emulsifier in intravenous fat emulsions. It also serves as a solubilizing and stabilizing agent, helping maintain the clarity of elixirs and syrups.

Furthermore, it can act as a wetting agent and is commonly used in ointments, suppository bases, and gels. It also functions as a binder and coating material in tablet formulations.